Specific genes influence sensitivity to stimuli in our genetic makeup. Here are some genes and their variants that may impact this trait.
NLN and DBH GenesÂ
The rs16894446Â in gene NLN has emerged as a significant SNP in influencing sensitivity to stimuli. Major allele homozygotes for rs16894446 reported higher sensitivity on the Highly Sensitive Personality (HSP) scale. This implies that individuals with a specific genetic makeup at this locus are more prone to heightened sensory awareness.
In the case of rs895379 in NLN, major allele homozygotes were associated with lower sensitivity on the HSP scale. This illustrates the diversity of genetic influences, as certain alleles can contribute to a lesser degree of sensitivity in individuals compared to others.
For another SNP in NLN, rs2561196, the minor allele homozygotes reported less sensitivity on the HSP scale.
Similarly, rs1611123Â in gene DBH (dopamine beta-hydroxylase) exhibited a notable effect on sensitivity. Major allele homozygotes for rs1611123 reported higher sensitivity on the HSP scale. This suggests a link between the genetic variations at this locus and an individual’s responsiveness to stimuli, contributing to their overall sensory experience.
TH and INS genes
For the TH gene SNP rs4929966, being heterozygotes was associated with higher sensitivity on the HSP scale. This gene variant highlights the role of genetic diversity in influencing sensitivity, with heterozygous individuals experiencing a different level of sensory responsiveness compared to major allele homozygotes or minor allele homozygotes.
The rs3842748 situated between genes TH and INS, displayed a similar connection between genetic makeup and sensitivity. Heterozygotes for rs3842748 reported higher sensitivity on the HSP scale. This reinforces the idea that specific genetic variations contribute to an individual’s predisposition to heightened sensory experiences.
NTRS1 and NTSR2 genes
Contrasting with the previous genes, major allele homozygotes for rs7131056 in gene NTRS1 reported higher sensitivity on the HSP scale. This variation highlights the intricate interplay of different genetic factors, with specific alleles contributing to diverse sensitivities in individuals.
However, for heterozygotes of rs6062460 in NTSR1, a lower sensitivity on the HSP scale was reported. This gene variant adds another layer of complexity to the genetic basis of sensitivity, indicating that the combination of alleles at this locus plays a role in modulating an individual’s sensory experiences.
Additionally, for rs12612207 in the NTSR2 gene, the minor allele homozygotes reported less sensitivity on the HSP scale.
SLC6A3 gene
For the variant rs2975292, the minor allele homozygotes reported less sensitivity on the HSP scale. This highlights the significance of specific genetic variations in influencing sensitivity, with individuals carrying minor alleles exhibiting a different sensory response than major allele homozygotes or heterozygotes.
In summary, these genetic findings underscore the intricate relationship between specific gene, variants, different alleles, and their combinations, and sensitivity to stimuli, emphasizing the polygenic nature of this trait. Each gene contributes uniquely to an individual’s sensory experiences, and their combined effects shape the overall sensitivity observed on the HSP scale.