DNA and Skincare: The Genetics of Psoriasis

Aira on August 8, 2024

Many skin conditions plague millions of people all over the world. Some of them are more serious than others, causing changes in lifestyle and the quality of life of the individual who has them. One of the most common skin conditions is psoriasis. Although technically, psoriasis is an autoimmune disease, its effects are most commonly seen in a person’s physical appearance. 

 

Psoriasis has a high likelihood of being hereditary, meaning that genetics play a role in the development of this disorder. Genetic testing for psoriasis can help you determine whether you are at risk or not. LifeDNA offers full and comprehensive information about your skincare and its relationship with your genetic variation. 

Psoriasis and Other Genetic Skin Traits

Psoriasis can cause inflammation, redness, and itchy scale-like scabbing on the skin, scalp, knees, elbows, hands, feet, and other parts of the body. As your body produces new skin cells, the immune cells in your blood mistake them for foreign invaders and attack these new skin cells which causes an overproduction of new skin cells beneath your skin. They force out the existing skin cells which results in scabbing and a scale-like appearance of the skin. 

 

According to studies, genetics play an important role in determining if a person will develop psoriasis or not. While there are cases wherein a person with psoriasis has no family history of the disease, the likelihood of developing it goes up to 50 percent if one or both parents has a history of the autoimmune disorder. 

 

Psoriasis is also more commonly seen in adults compared to eczema which is often diagnosed in children. The two can be very similar in symptoms so a dermatologist may need to run multiple tests to be sure. Excessive stress and allergens can also be contributing factors to developing psoriasis. 

 

Other skin conditions can also be genetic. Some of them can cause extreme pain or discomfort and affect an individual’s self-esteem. Knowing more about DNA skincare can help you manage these conditions or prevent them from developing.

Life DNA

Acne

A common skin condition mostly seen as a dilemma for teenagers and young adults, acne may vary in severity. When the skin produces too much sebum, your follicles can clog and pimples may form. These pimples may multiply and be inflamed for a period of time. Acne can be uncomfortable but is highly treatable.

Facial Wrinkles

As the dreaded evidence of aging, wrinkles are considered an enemy of many people. They can be the result of lifestyle, sun damage, smoking, excessive alcohol, and genetics. They appear as fine lines and skin furrows, giving the skin an “old-weathered” look. 

Varicose Veins

Varicose veins (VVs) commonly appear on the legs. They are swollen and twisted veins that can be a pain both medically and aesthetically. They can cause swelling of the legs and feet as well. While not usually painful, they can cause muscle cramps, swelling, and itching. 

Rosacea 

A chronic condition, rosacea is an inflammatory skin condition. It primarily affects areas of the face such as the cheeks, forehead, nose, and chin. It is most common and evident in fair-skinned people because they cause the skin to appear red, flushed, and sometimes a bit swollen. While not curable, rosacea is manageable with certain topical and oral medications.

 

Want to know more about your genetic likelihood of developing psoriasis and unlock personalized skincare suggestions to help prevent and manage this condition? Unlock LifeDNA’s DNA skincare report today. 

Personalized Beauty Insights from LifeDNA’s DNA Skincare Test

Life DNA

Skincare is one of the most popular and valuable industries in the world today. There are thousands upon thousands of beauty and cosmetic companies that produce millions of skincare products. If you suspect you are prone to certain skin conditions due to your genetic variation, try a skin DNA test. 

A skincare routine will highly depend on your skin’s suitability. Genetics will also play an important role in managing certain skin conditions and even influence their development in the first place. Want to get reveal your most beautiful complexion based on personalized skincare insights? Try LifeDNA today. 

*Understanding your genetics can offer valuable insights into your well-being, but it is not deterministic. Your traits can be influenced by the complex interplay involving nature, lifestyle, family history, and others.

Our reports have not been evaluated by the Food and Drug Administration. The contents on our website and our reports are for informational purposes only, and are not intended to diagnose any medical condition, replace the advice of a healthcare professional, or provide any medical advice, diagnosis, or treatment. Consult with a healthcare professional before making any major lifestyle changes or if you have any other concerns about your results. The testimonials featured may have used more than one LifeDNA or LifeDNA vendors’ product or reports.

Is Your Ability to Smell Beta-Ionone Genetic?

Aira on June 17, 2024

Overview

Ever wonder why some people can’t stand the smell of violets while others find it delightful? The answer lies in a fascinating compound called beta-ionone. Beta-ionone is a naturally occurring organic compound that plays a significant role in the fragrance profiles of various flowers and plants. 

The ability to detect beta-ionone can indeed be influenced by genetics. People with certain genetic variants can perceive the aroma of beta-ionone more intensely, while others may find it nearly odorless. This genetic predisposition is akin to the well-known phenomenon of supertasters, where specific genetic makeup influences taste perception.

Understanding these genetic differences not only provides insight into human sensory diversity but also has practical implications in fields like perfumery and food flavoring, where tailored experiences based on scent perception can enhance consumer satisfaction or even just the human experience.

You May Also Like: The Genetics of Bitter Taste Perception

Ability to Smell Beta-Ionone

What is Beta-Ionone?

Beta-ionone is a fascinating compound that you’ve probably encountered without even knowing it. It’s a naturally occurring organic compound found in various flowers and plants, most notably in violets and roses. This compound belongs to a family of chemicals called ionones, which are derived from the breakdown of carotenoids – the pigments that give carrots their orange color.

What makes beta-ionone particularly interesting is its role in scent perception. This compound has a sweet, floral aroma that is widely used in the perfume industry and in flavoring agents. However, not everyone can detect beta-ionone in the same way, and this variation is largely due to genetics.

The ability to detect beta-ionone is not evenly distributed across all populations. This genetic predisposition offers a glimpse into the complex relationship between human genes and an individual’s sensory experiences.

Where is Beta-Ionone Used?

Beta-ionone is a versatile compound with a wide array of uses that extend beyond its intriguing scent. Found naturally in flowers like violets and roses, beta-ionone’s sweet, floral aroma makes it a popular choice in several industries.

In the perfume industry, beta-ionone is a prized ingredient. Its pleasant fragrance is often used to create floral notes in perfumes and colognes, adding depth and complexity to the scent profile. Perfumers value beta-ionone for its ability to evoke the smell of fresh flowers, enhancing the appeal of their creations.

Beyond perfumery, beta-ionone is also significant in the world of flavoring. It is used as a flavoring agent in various food and beverage products, contributing to the fruity and floral flavors in items like candies, baked goods, and beverages. Its ability to mimic natural flavors makes it a valuable addition to many culinary products, enriching the sensory experience of food.

The cosmetic industry also benefits from beta-ionone’s properties. It is frequently incorporated into skincare and haircare products for its fragrant qualities. Lotions, creams, shampoos, and conditioners often contain beta-ionone to impart a pleasant scent that enhances the user experience.

Interestingly, beta-ionone has also found a place in aromatherapy. Its calming floral aroma is believed to have relaxing and mood-lifting effects, making it a popular choice for essential oils and diffusers.

Understanding the diverse uses of beta-ionone underscores the importance of genetic variations in our sensory perceptions. For those with heightened sensitivity to this compound, products containing beta-ionone can offer a more intense and enjoyable experience, illustrating how genetics can influence our preferences and lifestyle choices in subtle yet meaningful ways.

Is Sensitivity to Beta-Ionone Genetic?

A 2013 research shows that sensitivity to odors is often inherited, with genetic variations usually found near olfactory receptor (OR) genes. However, because there are thousands of different aromas and few known ORs, linking specific OR genes to odor sensitivity has been challenging.

Scientists believe that variations in OR genes explain much of the differences in how people perceive odors, similar to how genetic differences affect taste and influence food flavors. Using a genome-wide association study, researchers examined sensitivity to ten food-related odors and found strong genetic associations for several, including 2-heptanone, isobutyraldehyde, β-damascenone, and β-ionone. Notably, the genetic association with β-ionone was particularly significant with a variant close to the OR4D6 gene.

These various genetic associations were found near distinct clusters of OR genes, increasing the known loci related to olfactory sensitivity to nine. This emphasizes the role of OR gene variations in our ability to detect food-related smells. Analysis of genetic data across different human populations suggests that sensitivity variations for these odors are common. Each individual carries a unique combination of sensitivities, leading to a personalized “flavor world” where everyone experiences odors and flavors differently.

A similar 2013 study focused on β-ionone alone, an aroma compound with notable sensitivity differences among individuals. β-ionone is used in many foods and beverages for its pleasant floral note. Through genome-wide and laboratory tests, researchers identified SNP rs6591536 G-allele as the key genetic variant responsible for β-ionone sensitivity. This variant causes an N183D substitution in the OR5A1 receptor and accounts for more than 96% of the observed differences in sensitivity, similar to a monogenic Mendelian trait. Notably, this genetic locus is highly linked with the locus discovered in the study described above.  

People with the sensitive genotype can more easily distinguish between foods and drinks with or without added β-ionone. They often describe β-ionone as “fragrant” and “floral,” while those with less sensitivity perceive these smells differently. The rs6591536 genotype not only affects sensory perception but also influences emotional responses and choices related to food and products.

This research demonstrates that specific olfactory receptor gene variants significantly impact how people experience and respond to foods, beverages, and other scented products, highlighting the profound effect of genetics on sensory experiences.

What Other Factors Affect Sensitivity to Beta-Ionone?

Sensitivity to beta-ionone, a fragrant compound found in flowers like violets and roses, is influenced not only by genetics but also by various environmental factors. Understanding these factors can provide a comprehensive view of how our environment interacts with our genetic makeup to shape our sensory experiences. Here are some key environmental factors that can affect sensitivity to beta-ionone:

  1. Air Quality: Air pollution and overall air quality can significantly impact our sense of smell. Exposure to pollutants like smoke, chemicals, and particulate matter can damage olfactory receptors, reducing sensitivity to scents, including beta-ionone. Studies have shown that individuals living in areas with high levels of air pollution often experience a diminished sense of smell compared to those in cleaner environments.
  2. Diet and Nutrition: What we eat can influence our olfactory sensitivity. Diets rich in certain vitamins and minerals, such as zinc and vitamin A, are essential for maintaining healthy olfactory function. Zinc deficiency, for example, is linked to a reduced sense of smell. Ensuring a balanced diet that supports overall health can help maintain or even enhance sensitivity to aromas like beta-ionone.
  3. Exposure to Chemicals: Frequent exposure to strong chemicals, such as cleaning agents, pesticides, and industrial solvents, can lead to olfactory fatigue or damage. These chemicals can impair the ability to detect and enjoy delicate scents. People working in environments with heavy chemical use should take precautions to protect their olfactory health.
  4. Age: Age is a natural factor that affects our sense of smell. As people age, the sensitivity of their olfactory receptors generally declines. This age-related decline can make it more challenging to detect scents, including beta-ionone. Maintaining good overall health and stimulating the sense of smell through varied scent experiences can help mitigate some of these effects.
  5. Health Conditions: Certain health conditions and illnesses can affect olfactory sensitivity. Respiratory infections, sinus issues, and neurological conditions like Alzheimer’s disease or Parkinson’s disease are known to impair the sense of smell. Even common conditions like allergies or colds can temporarily reduce sensitivity to scents.
  6. Medications: Some medications can influence the sense of smell as a side effect. For example, certain antibiotics, antidepressants, and blood pressure medications have been reported to affect olfactory function. If you notice changes in your ability to smell while taking medication, it’s advisable to consult with a healthcare professional.
  7. Smoking: Smoking is well-documented to impair the sense of smell. The chemicals in tobacco smoke can damage olfactory receptors, leading to a reduced ability to detect scents like beta-ionone. Quitting smoking can gradually improve olfactory sensitivity over time.
  8. Hormonal Changes: Hormonal fluctuations, such as those occurring during pregnancy, menstruation, or menopause, can impact the sense of smell. For instance, many women report heightened sensitivity to certain scents during pregnancy due to hormonal changes.
  9. Stress and Emotional State: Psychological factors, including stress and emotional well-being, can influence olfactory sensitivity. Chronic stress and anxiety can dampen the sense of smell, while a relaxed state might enhance it. Practices that reduce stress, such as mindfulness and relaxation techniques, may help maintain olfactory sensitivity.
  10. Environmental Enrichment: Exposure to a wide variety of scents in one’s environment can enhance olfactory sensitivity. Regularly engaging with different smells, whether through cooking, gardening, or using scented products, can keep the olfactory system stimulated and responsive.

By considering these environmental factors, individuals can better understand how their lifestyle and surroundings might affect their sensitivity to beta-ionone and other scents. Combining this knowledge with an awareness of genetic predispositions provides a fuller picture of the intricate dance between genes and the environment in shaping our sensory experiences.

What is the Difference Between Alpha-Ionone and Beta-Ionone?

Alpha-ionone and beta-ionone are two closely related compounds that belong to the ionone family, known for their significant roles in fragrances and flavors. Despite their similarities, they have distinct differences that influence their sensory profiles and applications.

Alpha-ionone and beta-ionone differ primarily in their chemical structure. Both are isomers, meaning they share the same molecular formula (C13H20O) but differ in the arrangement of their atoms. This structural difference affects how they interact with olfactory receptors, leading to variations in their scents.

Alpha-ionone is known for its woody, floral aroma. It is commonly found in essential oils and is a key component in many perfumes and cosmetic products. Its scent is often described as reminiscent of violets but with a warmer, earthier undertone.

Beta-ionone, on the other hand, has a sweet, floral fragrance that is distinctly reminiscent of violets. It is used extensively in the perfume industry to create floral notes and is also a popular flavoring agent in foods and beverages due to its pleasant aroma.

What are Some Benefits of Beta-Ionone?

Beta-ionone offers a range of benefits that extend beyond its pleasing floral aroma. Here are some key advantages:

  1. Fragrance and Flavor Enhancement: Beta-ionone is widely used in the perfume industry to create rich, floral notes reminiscent of violets and roses. It adds depth and complexity to fragrances, making them more appealing. In the food industry, beta-ionone serves as a flavoring agent, enhancing the taste of various products like candies, beverages, and baked goods.
  2. Aromatherapy Benefits: Beta-ionone is believed to have calming and mood-lifting effects. Used in aromatherapy, it can help reduce stress and promote relaxation. Its sweet, soothing scent is often found in essential oils and diffusers, contributing to a tranquil atmosphere.
  3. Antioxidant Properties: Research indicates that beta-ionone possesses antioxidant properties, which can help protect cells from oxidative stress and damage. This makes it beneficial in formulations for skincare and health supplements, potentially contributing to overall well-being.
  4. Potential Anti-inflammatory Effects: Some studies suggest that beta-ionone may have anti-inflammatory properties, which could be useful in managing conditions associated with inflammation. This potential benefit is still under investigation but shows promise for future therapeutic applications.

Understanding these benefits highlights how beta-ionone not only enhances sensory experiences but also offers potential health and wellness advantages via odor reception, underscoring the intricate link between our environment, genetics, and lifestyle.

How to Improve Sensitivity to Beta-Ionone

Improving sensitivity to beta-ionone, a fragrant compound found in violets and other flowers, can enhance the enjoyment of perfumes, foods, and other scented products. While genetic predisposition plays a significant role, several strategies can help boost olfactory sensitivity. Here are some scientifically backed methods to enhance your ability to detect beta-ionone:

Maintain Good Overall Health

A healthy body supports a healthy sense of smell. Regular exercise improves blood circulation, which helps maintain the health of olfactory receptors. A balanced diet rich in essential nutrients like zinc and vitamin A is crucial for olfactory function. Zinc is particularly important as it plays a role in cell repair and regeneration, including in the olfactory system. Foods high in zinc include meats, shellfish, legumes, and nuts.

Avoid Exposure to Pollutants

Air pollution, smoke, and harsh chemicals can damage olfactory receptors and diminish sensitivity. Reducing exposure to these pollutants by avoiding smoking, using air purifiers, and choosing natural cleaning products can help preserve and enhance your sense of smell. If you live in an area with high air pollution, consider spending time in cleaner environments whenever possible.

Regular Olfactory Training

Engaging in olfactory training can significantly improve sensitivity to specific scents, including beta-ionone. This practice involves regularly exposing yourself to a variety of smells in a focused manner. Studies have shown that olfactory training can enhance the brain’s ability to recognize and differentiate scents. You can start with common scents like lemon, eucalyptus, and clove, gradually incorporating beta-ionone-containing items like violet-scented products.

Minimize Stress

Chronic stress and anxiety can negatively impact your sense of smell. Stress management techniques such as mindfulness, meditation, yoga, and regular exercise can improve overall mental well-being and, consequently, olfactory sensitivity. A relaxed state helps the olfactory system function more effectively.

Stay Hydrated

Proper hydration is essential for all bodily functions, including olfactory sensitivity. Dry mucous membranes in the nasal passages can hinder scent detection. Drinking plenty of water helps keep these membranes moist, facilitating better scent perception.

Limit Exposure to Strong Chemicals

Frequent exposure to strong chemicals found in cleaning agents, pesticides, and industrial solvents can cause olfactory fatigue or damage. Use natural or less harsh products and ensure good ventilation when using chemicals to protect your olfactory receptors.

Quit Smoking

Smoking is a well-known inhibitor of olfactory function. The chemicals in tobacco smoke can damage olfactory receptors, reducing sensitivity to scents like beta-ionone. Quitting smoking can lead to gradual improvement in your sense of smell as the receptors regenerate over time.

Engage in Scent Enrichment Activities

Regularly exposing yourself to a wide range of scents can stimulate and enhance olfactory sensitivity. Activities such as cooking with aromatic herbs and spices, gardening with fragrant flowers, and using moderately scented candles or essential oils can provide a rich sensory environment that keeps the olfactory system engaged and responsive.

Manage Health Conditions

Addressing health conditions that affect the sense of smell, such as sinus infections, allergies, and nasal polyps, can improve olfactory sensitivity. Treating these conditions with the help of a healthcare professional ensures that your nasal passages and olfactory receptors remain healthy and functional.

Consult with a Healthcare Professional

If you notice a significant decline in your ability to detect scents, it may be helpful to consult with an otolaryngologist (ear, nose, and throat specialist). They can provide insights and treatments tailored to improve your olfactory function.

By incorporating these strategies into your daily routine, you can enhance your sensitivity to beta-ionone and other scents, enriching your sensory experiences and overall quality of life. Understanding how lifestyle and environmental factors interact with genetic predispositions offers a holistic approach to maintaining and improving the sense of smell.

LifeDNA’s Sensitivity to Beta-Ionone Odor Trait Report

Discover how your unique genetic makeup influences your sensitivity to beta-ionone with LifeDNA’s Sensitivity to Beta-Ionone Odor Report. This scientifically-backed analysis is part of LifeDNA’s Personality and Cognition Report, designed to help you understand how your genetics shape your sensory experiences, lifestyle habits, and overall well-being.

LifeDNA’s detailed genetic reports go beyond basic insights. They provide a deep dive into over 200 trait reports available under various categories, including Nutrition, Wellness, Vitamins and Supplements, Fitness, Sleep, and Skincare. Our premium offerings, such as the Aging Report and Methylation Genes Report, provide targeted information to help you manage your health as you age.

By availing of LifeDNA’s reports, you can tailor your wellness journey to fit your unique genetic profile. Whether it’s optimizing your fitness routine, enhancing your sleep quality, choosing the right skincare products, or understanding your vitamin and supplement needs, LifeDNA equips you with the knowledge to make informed decisions.

Understanding your sensitivity to beta-ionone, for instance, can enhance your appreciation of fragrances and flavors, enrich your sensory experiences, and even inform your choices in aromatherapy. This insight, combined with the broader spectrum of LifeDNA’s reports, offers a holistic approach to personal wellness. Take the first step towards a personalized health journey. Explore LifeDNA’s plans and unlock the secrets of your unique genetic profile for a better, more informed you.

Summary

  • Humans vary in their ability to smell odors, with genetic variations near olfactory receptor (OR) genes contributing to these differences.
  • Genetic variation in OR genes affects odor perception and food selection, similar to how genetic differences influence taste.
  • Beta-ionone, a key aroma in foods and beverages, shows extreme sensitivity differences among individuals due to genetics.
  • The genetic variant rs6591536, causing an N183D substitution in OR5A1, is responsible for β-ionone odor sensitivity differences.
  • This variant explains over 96% of observed phenotypic variation, making it similar to a monogenic Mendelian trait.
  • People with the sensitive genotype for β-ionone describe it as “fragrant” and “floral,” while less-sensitive individuals perceive it differently.
  • Sensitivity to β-ionone also influences emotional associations and food/product choices.
  • Understanding genetic variations in OR genes highlights the significant impact of genetics on sensory experiences.
  • Air quality, diet and nutrition, exposure to chemicals, age, health conditions, medications, smoking, hormonal changes, stress, and environmental enrichment can affect sensitivity to beta-ionone.
  • Maintaining good health, avoiding pollutants, regular olfactory training, minimizing stress, staying hydrated, limiting strong chemicals, quitting smoking, engaging in scent enrichment activities, managing health conditions, and consulting healthcare professionals can improve sensitivity to beta-ionone.
  • Alpha-ionone has a woody, floral aroma, while beta-ionone has a sweet, floral fragrance, both are used in perfumes and flavors.
  • Beta-ionone enhances fragrances and flavors, offers aromatherapy benefits, has antioxidant properties, and has potential anti-inflammatory effects.
  • Sensitivity to beta-ionone is influenced by genetics, with specific OR gene variants significantly impacting odor detection and sensory experiences.

References

  1. https://pubchem.ncbi.nlm.nih.gov/compound/beta-Ionone
  2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069406/
  3. https://www.aftelier.com/Beta-Ionone-p/bot-nsio-betaionone.htm#:~:text=Beta%20Ionone%20can%20be%20used,personal%20and%20beautiful%20violet%20note.
  4. https://foodb.ca/compounds/FDB015469#:~:text=Beta%2Dionone%20has%20a%20dry,876d)%20and%20coml%20oil.
  5. https://cosmetics.specialchem.com/inci-ingredients/beta-ionone
  6. https://www.researchgate.net/figure/b-Ionone-as-a-fragrance-compound-in-the-essential-oils-of-various-plant-species_fig2_350844312
  7. https://www.sciencedirect.com/topics/chemistry/ionone
  8. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10142927/
  9. https://fraterworks.com/blogs/information/understanding-ionones#:~:text=Alpha%20ionone%20with%20its%20woody,root%20tincture)%20and%20violet%20leaves.
  10. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069406/#:~:text=%CE%B2%2DIonone%20and%20other%20apocarotenoids,have%20antibacterial%20and%20fungicidal%20properties.
  11. https://brieflands.com/articles/zjrms-7364#:~:text=Beta%2Dionone%20(Figure%201),activities%20%5B11%2C%2012%5D.
  12. https://www.ncbi.nlm.nih.gov/books/NBK567741/#:~:text=Olfactory%20training%20is%20a%20non,for%20at%20least%2024%20weeks.

*Understanding your genetics can offer valuable insights into your well-being, but it is not deterministic. Your traits can be influenced by the complex interplay involving nature, lifestyle, family history, and others.

Our reports and suggestions do not diagnose or treat any health conditions or provide any medical advice. Consult with a healthcare professional before making any major lifestyle changes or if you have any other concerns about your results.

Sagging Eyelids? Your Age and Genetics May Be the Reason

Aira on June 12, 2024

Overview

Ever looked in the mirror and noticed your eyelids drooping more than they used to? Eyelid sagging, also known as dermatochalasis, is a common condition that affects the appearance and function of the eyes.

Eyelid sagging occurs when the muscles responsible for lifting the eyelids weaken or the skin loses its elasticity. This can lead to a tired or aged appearance and, in severe cases, can impair vision. Various factors contribute to eyelid sagging, including aging, which is the most prevalent cause. 

While eyelid sagging is often associated with older adults, it can affect people of all ages, including children. Understanding the underlying causes and potential treatments is essential for managing and mitigating the impact of eyelid sagging on both appearance and eye health.

Sagging Eyelids

What is Eyelid Sagging?

Age-related eyelid sagging or drooping, in the form of dermatochalasis or ptosis, are common conditions that occur as part of the natural aging process. As people age, the skin and muscles around the eyes undergo changes that lead to the drooping of the upper eyelids. The primary factors contributing to this condition include the weakening of the levator muscles, which are responsible for lifting the eyelids, and the loss of skin elasticity due to decreased collagen production.

The skin around the eyes is particularly delicate and thin, making it more susceptible to the effects of aging. Over time, the connective tissues that support the eyelids can stretch and weaken, causing the eyelids to droop. This can give the face a tired or aged appearance and, in more severe cases, can obstruct vision.

Genetics plays a significant role in age-related eyelid sagging. If your parents or close relatives experienced ptosis, you are more likely to develop it as well. Additionally, lifestyle factors such as prolonged sun exposure, smoking, and poor skincare can accelerate the aging process and exacerbate eyelid sagging. For example, UV radiation from the sun can break down collagen and elastin fibers in the skin, hastening its loss of firmness and elasticity. Understanding the interplay between genetics and lifestyle can empower individuals to take proactive steps in managing age-related eyelid sagging.

What Causes Eyelid Sagging?

Eyelid sagging can stem from a variety of causes. Understanding these causes helps individuals grasp how genetics, lifestyle, and health conditions can impact their appearance and eye health.

  • Aging: The most common cause of eyelid sagging is aging. As people get older, the levator muscles, which lift the eyelids, can weaken. Additionally, the skin around the eyes loses elasticity due to decreased collagen production, leading to droopy eyelids.
  • Genetics: Genetics plays a significant role in eyelid sagging. If your parents or grandparents had ptosis, you’re more likely to experience it. This genetic predisposition affects the structure and strength of the eyelid muscles and skin.
  • Medical Conditions: Several medical conditions can cause or exacerbate eyelid sagging. Myasthenia gravis, a disease that disrupts the communication between nerves and muscles, often leads to eyelid sagging. Neurological disorders, like Horner’s syndrome, and systemic conditions such as diabetes can also weaken the eyelid muscles.
  • Trauma and Surgery: Trauma to the eye or surrounding area can damage the muscles or nerves responsible for eyelid movement. Similarly, previous eye surgeries can sometimes result in ptosis, either due to muscle damage or postoperative complications.
  • Lifestyle Factors: While less common, certain lifestyle factors can contribute to eyelid sagging. Chronic rubbing of the eyes, poor diet, and smoking can accelerate the loss of skin elasticity and muscle tone, leading to droopy eyelids.

Understanding these causes highlights the multifaceted nature of eyelid sagging. Genetics, health conditions, and lifestyle choices all interplay to influence whether someone might develop ptosis. Awareness of these factors can help individuals take proactive steps in managing their eye health and appearance.

Is Eyelid Sagging Genetic?

To uncover genetic risk factors for eyelid sagging, a 2018 genome-wide association (GWAS) study was conducted with 502 unrelated Caucasian women from the Paris region, aged between 44 and 70 years old, with an average age of 57.6 years. The severity of their eyelid sagging was categorized into six levels by a dermatologist using standardized facial photographs.

Taking into account potential risk factors such as age and smoking habits, this study identified significant genetic links to eyelid sagging. Specifically, two single nucleotide polymorphisms (SNPs) on chromosome 10, rs16927253 (P = 7.07 × 10^-10) and rs4746957 (P = 1.06 × 10^-8), were strongly associated with the severity of eyelid sagging. The rs16927253-T and rs4746957-A alleles showed a protective effect against eyelid sagging. These SNPs are found in the MACROH2A2 (a.k.a. H2AFY2) gene, which is part of the H2A histone family and are also near the AIFM2 gene, which induces apoptosis. 

Additionally, SNPs near the type XIII collagen COL13A1 gene on chromosome 10 and the ADAMTS18 gene on chromosome 16 were identified with a false discovery rate below 0.25, suggesting they might also play a role in eyelid sagging severity. This study highlights several genes that could be important in understanding the genetic factors behind eyelid sagging.

An older 2014 study aimed to identify both non-genetic and genetic risk factors for sagging eyelids. Researchers examined 5,578 unrelated Dutch Europeans from the Rotterdam Study and 2,186 twins from the UK Adult Twin Registry (TwinsUK). Participants’ eyelid sagging was assessed using digital photographs, with severity classified into four categories.

Key findings showed that 17.8% of the Rotterdam Study participants had moderate to severe dermatochalasis. Significant risk factors included age, male sex, lighter skin color, and higher body mass index (BMI). Current smoking was also borderline significant. The study estimated that 61% of the risk for sagging eyelids was due to genetics, based on data from 1,052 twin pairs from TwinsUK, where 15.6% showed dermatochalasis.

A GWAS involving participants from both cohorts identified a significant protective effect of the C-allele of rs11876749  in the DLGAP1 gene, near the TGIF1 gene, which is linked to skin aging. This genetic variant showed a recessive protective effect against sagging eyelids (P = 1.7 × 10^-8). 

The study concluded that, in addition to aging, factors such as male sex, genetic variants, lighter skin color, high BMI, and possibly smoking are involved in the development of sagging eyelids. Dermatochalasis is typically observed in middle-aged or older adults, leading to cosmetic concerns and potentially serious issues like visual field loss and headaches.

What Other Factors Can Affect Eyelid Sagging?

Eyelid sagging is influenced by various environmental factors that can accelerate the aging process and exacerbate the condition. Understanding these factors can help individuals take preventive measures to maintain their eyelid health. Here are the key environmental factors that can affect eyelid sagging:

  1. Sun Exposure: Prolonged exposure to ultraviolet (UV) radiation from the sun is one of the most significant environmental contributors to eyelid sagging. UV rays penetrate the skin and damage collagen and elastin fibers, which are essential for maintaining skin elasticity and firmness. Over time, this breakdown leads to thinner skin and increased sagging around the eyes. To protect against UV damage, it’s important to wear sunscreen with a high SPF, use sunglasses that offer UV protection and wear hats to shield the face from direct sunlight.
  2. Pollution: Air pollution, particularly in urban environments, exposes the skin to harmful particles and free radicals that can accelerate aging. Pollutants such as ozone, particulate matter, and nitrogen dioxide can cause oxidative stress, leading to inflammation and the degradation of skin proteins. This results in the loss of skin elasticity and firmness, contributing to eyelid sagging. Regular cleansing to remove pollutants and using skincare products with antioxidants can help mitigate these effects.
  3. Smoking: Smoking is a major environmental factor that accelerates the aging process, including the development of eyelid sagging. The chemicals in tobacco smoke cause vasoconstriction, reducing blood flow and depriving the skin of essential nutrients and oxygen. Additionally, smoking increases the production of free radicals, which damage collagen and elastin fibers. Studies have shown that smokers are more likely to develop wrinkles and sagging skin compared to non-smokers. Quitting smoking can significantly improve skin health and slow down the aging process.
  4. Diet and Nutrition: Diet plays a crucial role in skin health. A diet high in processed foods, sugars, and unhealthy fats can accelerate aging and contribute to eyelid sagging. Conversely, a diet rich in antioxidants, vitamins, and minerals can support collagen production and maintain skin elasticity. Key nutrients include vitamin C (found in citrus fruits, berries, and leafy greens), vitamin E (found in nuts, seeds, and green leafy vegetables), and omega-3 fatty acids (found in fish, flaxseeds, and walnuts). Staying hydrated by drinking plenty of water also helps maintain skin moisture and elasticity.
  5. Sleep Habits: Poor sleep habits can contribute to eyelid sagging and other signs of aging. During sleep, the body repairs and regenerates tissues, including the skin. Lack of sleep can lead to increased stress levels and the production of cortisol, a hormone that breaks down collagen. Ensuring adequate, quality sleep helps the skin to recover and maintain its firmness. It’s recommended to get 7-9 hours of sleep per night and practice good sleep hygiene, such as maintaining a consistent sleep schedule and creating a restful environment.
  6. Facial Expressions: Frequent or repetitive facial expressions can lead to the formation of wrinkles and sagging skin around the eyes. For example, squinting, frowning, or smiling can cause the skin to fold and crease. Over time, these expressions can contribute to the weakening of the skin and muscles around the eyes. Wearing sunglasses to reduce squinting and practicing facial relaxation techniques can help minimize these effects.
  7. Stress: Chronic stress affects the body in numerous ways, including the health of the skin. Stress triggers the release of cortisol, which can break down collagen and elastin fibers. This not only accelerates the aging process but also leads to the formation of wrinkles and sagging skin. Managing stress through activities like exercise, meditation, and mindfulness can help protect skin health.

By understanding and addressing these environmental factors, individuals can take proactive steps to protect their skin and potentially delay the onset of eyelid sagging. Combining a healthy lifestyle with good skincare practices can make a significant difference in maintaining youthful and firm eyelids.

Is Eyelid Sagging Permanent?

Age-related eyelid sagging is generally a permanent condition due to the natural aging process. While the condition itself is permanent, there are effective treatments available to address and manage eyelid sagging. 

Non-surgical options include the use of skin-firming creams and treatments that can temporarily tighten the skin around the eyes. For a more long-lasting solution, surgical procedures like blepharoplasty can remove excess skin and tighten the muscles, significantly improving the appearance of sagging eyelids.

Can You Prevent Eyelid Sagging?

Preventing age-related eyelid sagging entirely is not possible due to the natural aging process and genetic predisposition. However, there are several strategies to slow down the progression and minimize its effects. Here are some scientifically-backed methods to help maintain firm and youthful-looking eyelids:

  1. Protect Against UV Damage: Ultraviolet (UV) radiation from the sun is a significant factor in skin aging. UV rays break down collagen and elastin, leading to sagging skin. Wearing sunscreen with at least SPF 30, applying it around the eyes, and using sunglasses that block UV rays can protect the delicate skin of the eyelids from sun damage.
  2. Maintain a Healthy Diet: Nutrition plays a crucial role in skin health. A diet rich in antioxidants, vitamins, and minerals supports collagen production and skin elasticity. Key nutrients include.
  3. Vitamin C: Found in citrus fruits, berries, and leafy greens, it helps in collagen synthesis.
  4. Vitamin E: Present in nuts, seeds, and green leafy vegetables, protects skin from oxidative stress
  5. Omega-3 Fatty Acids: Found in fish, flaxseeds, and walnuts, they help maintain skin hydration and elasticity. Staying hydrated by drinking plenty of water is also essential for keeping the skin supple.
  6. Avoid Smoking: Smoking accelerates skin aging by reducing blood flow and depleting essential nutrients, causing the skin to lose its elasticity. The chemicals in tobacco smoke also increase the production of free radicals, which damage skin cells. Quitting smoking can significantly improve skin health and slow down the aging process.
  7. Practice Good Sleep Hygiene: Adequate sleep is vital for skin regeneration. During sleep, the body repairs and regenerates skin cells, including those around the eyes. Aim for 7 to 9 hours of quality sleep per night and practice good sleep hygiene, such as maintaining a consistent sleep schedule and creating a restful environment.
  8. Use Skincare Products: Incorporating anti-aging skin care products can help maintain skin firmness. Look for products containing:
  9. Manage Stress: Chronic stress increases cortisol levels, which can break down collagen and elastin. Managing stress through activities like yoga, meditation, and regular exercise can help protect skin health.
  10. Facial Exercises: Facial exercises can help strengthen the muscles around the eyes. Gentle exercises, such as raising the eyebrows and holding for a few seconds or lightly tapping the area around the eyes, can improve muscle tone and skin elasticity.

By incorporating these habits into daily life, individuals can help slow the progression of age-related eyelid sagging. While genetics play a significant role, lifestyle choices and preventive measures can make a considerable difference in maintaining youthful-looking eyes.

Ways to Treat Eyelid Sagging

Treating age-related eyelid sagging, or ptosis, involves a range of options from non-invasive therapies to surgical interventions. Here are some effective ways to address this condition, based on scientific evidence and expert recommendations:

Topical Treatments

Using anti-aging skincare products can help improve the appearance of sagging eyelids. Key ingredients include:

  • Retinoids: These vitamin A derivatives stimulate collagen production and enhance skin cell turnover, leading to firmer, smoother skin. Retinoids are available in prescription forms like tretinoin and over-the-counter options like retinol.
  • Peptides: Peptides are short chains of amino acids that signal the skin to produce more collagen and elastin. Products containing peptides can help improve skin firmness and elasticity around the eyes.
  • Hyaluronic Acid: This powerful humectant retains moisture, plumping the skin and reducing the appearance of sagging. It helps maintain skin hydration, making the eyelids look smoother and more youthful.

Non-Surgical Procedures

Several non-surgical treatments can effectively address eyelid sagging:

  • Botox: Botulinum toxin injections can lift the brow and reduce the appearance of drooping eyelids by temporarily paralyzing the muscles that pull the eyelids down. This creates a more lifted and youthful appearance.
  • Dermal Fillers: Hyaluronic acid-based fillers can add volume to the area around the eyes, reducing the appearance of sagging. They work by filling in hollows and supporting the skin structure.
  • Laser Therapy: Laser treatments, such as fractional CO2 lasers, can stimulate collagen production and tighten the skin around the eyes. These procedures help improve skin texture and firmness.
  • Radiofrequency (RF) Therapy: RF treatments use energy waves to heat the deep layers of the skin, stimulating collagen production and tightening the skin. This non-invasive procedure can be effective in reducing eyelid sagging.

Surgical Options

For more pronounced sagging, surgical intervention may be necessary:

  • Blepharoplasty: This is the most common surgical procedure for treating eyelid sagging. During blepharoplasty, excess skin, fat, and muscle are removed or repositioned to create a more youthful appearance. The procedure can be performed on the upper eyelids, lower eyelids, or both. It not only improves aesthetics but can also enhance vision if sagging eyelids obstruct the field of view.
  • Ptosis Surgery: If the sagging is due to muscle weakness, ptosis surgery can correct the underlying muscle dysfunction. This involves tightening or reattaching the levator muscle, which lifts the eyelid, resulting in a more open and alert eye appearance.

Lifestyle Modifications

Certain lifestyle changes can support the health of the skin around the eyes:

  • Healthy Diet: Consuming a diet rich in antioxidants, vitamins, and minerals can support skin health. Foods high in vitamin C, vitamin E, and omega-3 fatty acids are particularly beneficial for maintaining skin elasticity.
  • Sun Protection: Protecting the skin from UV damage is crucial. Wearing sunscreen, sunglasses, and hats can help prevent further sagging by reducing collagen breakdown.
  • Avoid Smoking: Smoking accelerates skin aging by decreasing blood flow and depleting essential nutrients. Quitting smoking can improve skin health and slow down the aging process.

Manage Chronic Conditions

Chronic health conditions such as diabetes, hypertension, and high cholesterol can increase the risk of hearing loss. Managing these conditions through medication, lifestyle changes, and regular medical check-ups can help prevent or delay the onset of age-related hearing loss.

Regular Skincare Routine

Adopting a consistent skincare routine can help maintain the firmness of the eyelid skin:

  • Cleansing: Gently cleanse the skin around the eyes to remove dirt and pollutants that can contribute to skin aging.
  • Moisturizing: Use a hydrating eye cream to keep the skin around the eyes moisturized and supple.
  • Antioxidants: Incorporate products with antioxidants, such as vitamin C serums, to protect the skin from free radical damage.

Facial Exercises

Facial exercises can strengthen the muscles around the eyes, potentially reducing sagging. Simple exercises, such as raising the eyebrows and holding for a few seconds or gently tapping the area around the eyes, can help tone the muscles and improve skin elasticity.

By combining these treatments and lifestyle changes, individuals can effectively manage age-related eyelid sagging. While genetics play a significant role, proactive measures can significantly enhance the appearance and health of the eyelids.

LifeDNA’s Age-Related Eyelid Sagging Trait Report

Discover the key to maintaining youthful eyes with LifeDNA’s Eyelid Sagging Trait Report. As we age, understanding how our genetics influence the aging process becomes crucial. LifeDNA offers a comprehensive Aging Report that delves into your unique genetic profile, helping you understand your body’s needs as you grow older.

LifeDNA’s Eyelid Sagging Trait Report is part of an extensive suite of over 200 trait reports available under various categories, including Nutrition,  Wellness, Vitamins and Supplements, Fitness, Personality and Cognition, Sleep, and Skincare. Our scientifically backed insights provide personalized recommendations to help you tackle eyelid sagging and other age-related changes.

By availing of LifeDNA’s reports, you gain access to tailored advice based on your genetic makeup. Whether you want to improve your skin health, optimize your nutrition, enhance your fitness routine, or understand your sleep patterns, LifeDNA has you covered. Our Premium Reports, like the AgingReport and Methylation Genes Report, offer in-depth analysis and actionable insights that empower you to take control of your wellness journey.

LifeDNA makes it easy to start your path to better health. With personalized recommendations, you can make informed decisions about your skincare routine, dietary choices, and overall wellness. Our reports highlight the importance of genetics in your daily habits and lifestyle, guiding you to achieve optimal health.

Begin your wellness journey today with LifeDNA’s plans. Embrace a future where you understand your body better and make choices that align with your genetic predispositions. Get started with LifeDNA and take the first step towards a healthier, more vibrant you. Explore our range of reports and see how your unique genetic profile can shape a better tomorrow.

Summary

  • Eyelid sagging, in the forms of dermatochalasis and ptosis, affects both appearance and eye function, often leading to a tired look and impaired vision.
  • Aging is a primary cause, as eyelid muscles weaken and skin loses elasticity.
  • While common in older adults, sagging eyelids can affect any age group, including children.
  • Genetic predisposition plays a significant role in eyelid sagging.
  • Lifestyle factors like sun exposure, smoking, and poor skincare can accelerate eyelid sagging.
  • Medical conditions such as myasthenia gravis and neurological disorders can also cause ptosis.
  • Trauma and surgery around the eyes can lead to eyelid sagging due to muscle damage.
  • Environmental factors like pollution and poor diet contribute to the aging of the skin around the eyes.
  • Protective measures include using sunscreen, maintaining a healthy diet, quitting smoking, and ensuring adequate sleep.
  • Genetic studies have identified SNPs near certain genes that influence eyelid sagging severity.
  • Non-surgical treatments include skin-firming creams, Botox, dermal fillers, laser therapy, and radiofrequency therapy.
  • Surgical options like blepharoplasty and ptosis surgery offer more permanent solutions to severe eyelid sagging.
  • A consistent skincare routine and facial exercises can help maintain skin firmness around the eyes.
  • Understanding genetic and environmental factors can help individuals manage and prevent eyelid sagging effectively.

References

  1. https://emedicine.medscape.com/article/1212294-overview?form=fpf
  2. https://www.health.harvard.edu/staying-healthy/the-aging-eye-when-to-worry-about-eyelid-problems#:~:text=Ptosis.,can%20also%20cause%20this%20condition.
  3. https://www.healthline.com/health/eyelid-drooping
  4. https://www.ncbi.nlm.nih.gov/books/NBK500000/#:~:text=Horner%20syndrome%20is%20a%20rare,in%20the%20sympathetic%20nerve%20supply.
  5. https://www.infocusops.com/how-droopy-eyelids-can-affect-vision/#:~:text=Causes%20of%20Droopy%20Eyelids&text=Sun%20Exposure%3A%20Sun%20exposure%20negatively,it%20can%20cause%20droopy%20eyelids.
  6. https://www.healthline.com/health/droopy-eyelid-exercises#:~:text=Resistance%20workout,while%20trying%20to%20close%20them.
  7. https://columbuseyelid.com/blog/risk-factors-for-droopy-eyelids/#:~:text=There%20are%20a%20few%20steps,making%20people%20younger%20in%20appearance.
  8. https://www.medicinenet.com/how_do_you_fix_droopy_eyelids/article.htm
  9. https://health.clevelandclinic.org/the-best-options-for-droopy-eyelids-circles-and-sags
  10. https://procoal.co.uk/blogs/beauty/can-you-use-retinol-on-droopy-eyelids
  11. https://www.mayoclinic.org/tests-procedures/blepharoplasty/about/pac-20385174#:~:text=blepharoplasty%20is%20done-,How%20blepharoplasty%20is%20done,excess%20skin%20from%20the%20eyelids.
  12. https://www.healthdirect.gov.au/surgery/ptosis-surgery#:~:text=Ptosis%20surgery%20is%20an%20operation,causing%20your%20eyelid%20to%20sag.

*Understanding your genetics can offer valuable insights into your well-being, but it is not deterministic. Your traits can be influenced by the complex interplay involving nature, lifestyle, family history, and others.

Our reports and suggestions do not diagnose or treat any health conditions or provide any medical advice. Consult with a healthcare professional before making any major lifestyle changes or if you have any other concerns about your results.

Sodium Sensitivity and Genetics

Aira on May 31, 2024

Discover how genetics play a role in sodium sensitivity, impacting your health and dietary choices. Learn the science behind sodium and its genetic links.

Genetic Insights into the Risk of Repeated Falls

Aira on May 26, 2024

Overview

Repeated falls in older adults pose significant risks, impacting their quality of life and healthcare costs. Factors such as reduced muscle mass, muscle strength, and environmental hazards contribute to the vulnerability of older adults to falls. Studies indicate that a considerable percentage of older adults experience repeated falls, with risk factors including the use of antidepressants, depression, and limited physical activity. Falls in older adults are a leading cause of injury-related deaths, with about 36 million falls reported annually in the United States alone, leading to injuries that require medical treatment and restrict daily activities. Recurrent falls can result in functional decline, mortality, and a cascade of individual and socioeconomic problems, emphasizing the importance of preventive measures and comprehensive assessments to identify and address the risk factors associated with falls in older adults.

Risk of repeated falls

Increased Vulnerability with Repeated Falls

Research suggests that a single fall significantly increases the likelihood of experiencing another one.  This escalating risk stems from several factors.  First, a fall can lead to physical injuries like fractures, which can impair mobility and balance, making future falls more likely.  Second, the psychological impact of a fall can be substantial, with older adults developing a fear of falling that can lead to social isolation and decreased physical activity, which further increases fall risk.  Finally, recurrent falls are often a marker of underlying health conditions that contribute to falls, such as balance problems, muscle weakness, or cognitive decline.

Consequences of Repeated Falls

Repeated falls in older adults can have a cascading effect on their physical and mental well-being. Here’s a breakdown of the potential consequences:

Physical Consequences

  • Injuries: Falls can cause a range of injuries, from minor scrapes and bruises to serious fractures like hip fractures. Hip fractures can be particularly debilitating, often requiring surgery and extensive rehabilitation. In some cases, they can lead to a loss of independence and even increased mortality risk.
  • Pain: Both acute pain from injuries and chronic pain from conditions like arthritis can be exacerbated by falls, making it more difficult for older adults to stay active and mobile.
  • Reduced mobility: The fear of falling or physical limitations caused by injuries can lead to a decline in mobility. Older adults may become less likely to leave their homes or participate in activities they previously enjoyed, leading to a decrease in overall fitness and function.
  • Hospitalization: Serious injuries from falls often require hospitalization, which can be disruptive and stressful for older adults. It can also lead to a decline in functional abilities and an increased risk of institutionalization.

Mental and Emotional Consequences

  • Fear of falling: Fear of falling is a common consequence of a previous fall. This fear can significantly impact the quality of life, leading older adults to avoid activities they perceive as risky and restrict their social interactions.
  • Loss of confidence: Repeated falls can erode self-confidence and make older adults feel less independent. This can lead to feelings of helplessness and depression.

Social isolation: The fear of falling or physical limitations can lead to social isolation, as older adults may withdraw from activities or social gatherings for fear of falling again.

Overall Impact

The cumulative effect of these physical and mental consequences can be a significant decline in an older adult’s overall health and well-being.  Repeated falls can lead to a loss of independence, decreased quality of life, and even an increased risk of mortality.

How Genetics May Influence The Risk of Repeated Falls

Genetics can play a role in influencing the risk of repeated falls in older individuals. A large GWAS study conducted on the UK Biobank population revealed that falls have a genetic component, with about 35% of the variability in the likelihood of experiencing at least one incident fall and 45% of the variability in the risk for recurrent falls being attributed to genetic factors.

The study was conducted among over 89,000 cases and 362,000 controls. Despite the complex genetic architecture of fall risk, the study identified several previously indicated, and three novel fall-associated loci, and found a small but significant SNP-based heritability of 2.7% with these novel loci alone.

The three novel fall-associated loci were located at 7p21.3 (rs2709062), 19q12 (rs2111530), and 5q21.3 (rs243110). 

To highlight one of the new genetic loci; the variant rs2111530 maps close to the gene TSHZ3 and its antisense. TSHZ3 is a gene encoding a zinc-finger transcription factor that is suggested to have a role in cortical development and in the pathogenesis of neurodevelopmental disorders.

In addition, the studies on cerebellum tissue showed the highest gene expression enrichment for the 3 fall-associated variants, suggesting that biological processes related to movement control, locomotion, adaptation of posture, and dynamic regulation of balance may play a role in shaping the complex mechanisms underlying fall risk.

Additionally, the study found that the risk of falling also had positive genetic correlations with fractures, insomnia, neuroticism, depressive symptoms, and different medications, and negative genetic correlations with muscle strength, intelligence, and subjective well-being.

Non-Genetic Factors Influencing The Risk of Repeated Falls

Several factors contribute to the risk of repeated falls in older adults.  These can be broadly categorized into intrinsic and extrinsic factors.

Intrinsic Factors (Relating to the Individual)

  • Musculoskeletal issues: Age-related decline in muscle strength, balance, and flexibility makes falls more likely. Conditions like arthritis can further limit mobility and coordination.
  • Vision problems: Poor vision can impair depth perception and make it difficult to navigate uneven surfaces or obstacles, increasing fall risk.
  • Medical conditions: Certain medical conditions like Parkinson’s disease, dementia, or chronic pain can affect balance, gait, and cognitive function, all contributing to falls.
  • Medications: Some medications, particularly those affecting blood pressure or the nervous system, can cause dizziness or drowsiness, increasing fall risk. A medication review can help identify if adjustments are needed.

Foot problems: Foot pain, ill-fitting footwear, or poo

Extrinsic Factors (Environmental Hazards)

Additional Considerations

  • Fear of falling: A psychological consequence of a previous fall, the fear of falling can lead to social isolation and decreased physical activity, both of which further increase fall risk.
  • Nutritional deficiencies: Vitamin D deficiency, for example, can contribute to muscle weakness and bone health problems, both of which increase fall risk.

The Importance of Prevention

Given the significant risks associated with recurrent falls, prevention becomes paramount.  A multi-pronged approach that addresses both intrinsic and extrinsic factors is most effective.

Addressing intrinsic factors may involve:

  • Exercise programs to improve strength, balance, and flexibility
  • Vision assessments and correction of any impairments
  • Medication review to identify and potentially adjust medications that may affect balance
  • Physical therapy to address gait and balance issues

Modifying extrinsic factors includes:

  • Improving home safety by removing clutter, installing grab bars, and ensuring adequate lighting
  • Wearing proper footwear with good traction
  • Using assistive devices like canes or walkers when needed

About the LifeDNA Aging Report

Understanding your personal risk factors for falls can significantly help in preventing them, especially as you age. The LifeDNA Aging Report offers a comprehensive genetic analysis that provides personalized insights into various aspects of aging, including your risk for repeated falls. This report evaluates your genetic predisposition to falls and provides actionable health advice tailored to your unique genetic profile. By knowing your specific risks, you can take proactive measures such as modifying your home environment, adjusting your exercise routine, and consulting with healthcare providers to mitigate these risks effectively.

Empower yourself with knowledge and take control of your wellness journey. The LifeDNA Aging Report is a valuable tool that offers you the information needed to make informed decisions and adopt a proactive approach to aging. Don’t wait for a fall to happen – order your LifeDNA Aging Report today.

Summary

  • Repeated falls in older adults greatly affect their quality of life and healthcare costs.
  • Approximately 36 million falls are reported annually in the U.S., often leading to serious injuries and restricted daily activities.
  • Falls can cause severe injuries like fractures and reduced mobility, often leading to hospitalization.
  • Fear of falling and loss of confidence can result in social isolation and depression.
  • Genetics account for 35% of the variability in single falls and 45% in recurrent falls.
  • Key genetic loci associated with fall risk are SNPs rs2709062, rs2111530 near TSHZ3, and rs243110. 
  • Fall risk is genetically correlated with fractures, insomnia, neuroticism, depressive symptoms, muscle strength, and overall well-being.
  • Non-genetic factors of risk of repeated falls include musculoskeletal issues, vision problems, certain medical conditions, medications, and foot problems.
  • Home safety hazards and poor footwear significantly increase fall risk.
  • A comprehensive approach involving exercise, vision assessments, medication reviews, physical therapy, and home safety improvements is essential to reduce fall risk.

References

  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509467/
  2. https://www.msdmanuals.com/en-jp/professional/geriatrics/falls-in-older-adults/falls-in-older-adults
  3. https://www.sciencedirect.com/science/article/abs/pii/S0378512220304242
  4. https://www.cdc.gov/falls/facts.html
  5. https://www.ncbi.nlm.nih.gov/books/NBK235613/
  6. https://www.ncbi.nlm.nih.gov/books/NBK557971/
  7. https://www.nature.com/articles/s42003-020-01256-x
  8. https://www.msdmanuals.com/professional/geriatrics/falls-in-older-adults/falls-in-older-adults
  9. https://www.nia.nih.gov/health/falls-and-falls-prevention/falls-and-fractures-older-adults-causes-and-prevention
  10. https://www.researchgate.net/publication/11471956_Preventing_falls_in_older_people_Impact_of_an_intervention_to_reduce_environmental_hazards_in_the_home

*Understanding your genetics can offer valuable insights into your well-being, but it is not deterministic. Your traits can be influenced by the complex interplay involving nature, lifestyle, family history, and others.

Our reports have not been evaluated by the Food and Drug Administration. The contents on our website and our reports are for informational purposes only, and are not intended to diagnose any medical condition, replace the advice of a healthcare professional, or provide any medical advice, diagnosis, or treatment. Consult with a healthcare professional before making any major lifestyle changes or if you have any other concerns about your results. The testimonials featured may have used more than one LifeDNA or LifeDNA vendors’ product or reports.

Can Age-related Hearing Loss Be Genetic?

Aira on May 24, 2024

Overview

Hearing loss is often perceived as a natural consequence of aging, silently encroaching on the quality of life for millions worldwide. However, the consequences of age-related hearing loss (ARHL) extend far beyond mere inconvenience. Delving into the reasons behind this phenomenon reveals genetic predispositions, environmental influences, and physiological changes.

What is Hearing Loss?

Hearing loss is a multifaceted phenomenon influenced by various genetic, environmental, and lifestyle factors. At its core, hearing loss often stems from damage to the delicate structures within the inner ear responsible for detecting sound waves and transmitting them to the brain for interpretation. This damage can manifest in several ways.

Genetic predispositions play a significant role in determining an individual’s susceptibility to hearing loss. Research has identified numerous genes associated with hearing impairment, including those involved in the development and maintenance of crucial auditory structures like the hair cells and the cochlea. Variations in these genes can affect how effectively the inner ear functions, increasing the likelihood of hearing loss over time. Environmental factors also play a pivotal role in hearing health. 

The aging process itself contributes to hearing loss, a condition known as presbycusis. As individuals grow older, the structures within the inner ear naturally deteriorate, leading to a decline in hearing acuity. This age-related decline is often compounded by genetic predispositions and environmental exposures, highlighting the complex interplay of factors influencing hearing health.

Age-related hearing loss

When Does Age-related Hearing Loss Usually Start?

Age-related hearing loss typically begins to manifest in individuals as they enter their 40s or 50s, although the effects may not become noticeable until later in life. Research indicates that the prevalence of age-related hearing loss increases with advancing age, with a significant rise observed after the age of 65. By the age of 75, approximately half of all individuals experience some degree of hearing impairment.

The gradual onset of age-related hearing loss is often attributed to a combination of genetic predispositions and cumulative exposure to environmental factors over time.

Is Age-related Hearing Loss Genetic?

A 2014 study investigated the genetics behind age-related hearing loss by analyzing data from different groups of people across Europe and Asia. They looked at over 2 million genetic variations in nearly 5,000 individuals and found that a specific gene, called salt-inducible kinase 3 (SIK3), was linked to hearing ability. This gene was particularly associated with how well people could hear different pitches of sound.

Further studies on mice showed that the mouse Sik3 gene is expressed in the cells of the inner ear during both early development and adulthood. This suggests that the SIK3 kinase may play a role in the development and maintenance of hearing throughout life.

This study found that that one genetic variant, the SNP rs681524 in the SIK3 gene seems to influence how well people can hear as they get older. Understanding the role of this genetic variant could help scientists develop new treatments for age-related hearing loss in the future.

To uncover more about the genetic factors behind ARHL, a 2019 research revealed data from over 250,000 volunteers aged 40 to 69. They found 44 specific genetic regions linked to hearing loss including genes ​​EYA4, TRIOBP, ARHGEF28, NID2, and CTBP2. Interestingly, 34 of these regions were newly discovered, shedding light on previously unknown factors contributing to hearing loss.

These genetic regions are related to various aspects of hearing, such as how the inner ear works and how the brain processes sound. Surprisingly, some of these genetic regions were also linked to personality traits and psychological characteristics for the first time. This research opens up new avenues for developing treatments for age-related hearing loss and highlights the importance of genetic factors in understanding the condition.

What Other Factors Can Influence Age-related Hearing Loss?

Environmental factors play a significant role in influencing age-related hearing loss, contributing to its onset and progression alongside genetic predispositions. Understanding these environmental influences is crucial for individuals seeking to protect their hearing health as they age. Here are several key environmental factors that can affect age-related hearing loss:

  1. Noise Exposure: Prolonged exposure to loud noises is one of the most significant environmental risk factors for hearing loss. Occupational noise, such as machinery or construction work, and recreational activities like attending concerts or using personal listening devices at high volumes can damage the delicate structures of the inner ear over time. The intensity and duration of noise exposure play crucial roles in determining the extent of hearing damage.
  2. Ototoxic Chemicals: Certain chemicals and medications have been identified as ototoxic, meaning they can damage the auditory system and contribute to hearing loss. Common ototoxic substances include certain antibiotics, chemotherapy drugs, and heavy metals like lead and mercury. These substances can disrupt the function of hair cells in the inner ear or damage the auditory nerve, leading to hearing impairment.
  3. Smoking: Smoking has been linked to an increased risk of hearing loss. The toxins in cigarette smoke can restrict blood flow to the inner ear, depriving it of essential nutrients and oxygen. This diminished blood flow can accelerate the degeneration of auditory structures and contribute to age-related hearing loss. Additionally, smoking is associated with higher rates of cardiovascular disease, which further exacerbates the risk of hearing impairment.
  4. Cardiovascular Health: Poor cardiovascular health is a significant risk factor for age-related hearing loss. Conditions such as hypertension, atherosclerosis, and diabetes can compromise blood flow to the inner ear, impairing its function and leading to hearing impairment. Maintaining a healthy cardiovascular system through regular exercise, a balanced diet, and managing risk factors like high blood pressure can help preserve hearing health as individuals age.
  5. Diet and Nutrition: Certain dietary factors may influence the risk of age-related hearing loss. Research suggests that diets high in antioxidants, omega-3 fatty acids, and vitamins like vitamin A, vitamin C, and vitamin E may help protect against hearing loss by reducing oxidative stress and inflammation in the auditory system. Conversely, diets high in saturated fats, cholesterol, and processed foods may contribute to vascular damage and increase the risk of hearing impairment.
  6. Exposure to Environmental Toxins: Exposure to environmental toxins such as heavy metals, pesticides, and industrial chemicals may also contribute to age-related hearing loss. These toxins can accumulate in the body over time and disrupt cellular function in the auditory system, leading to hearing impairment. Minimizing exposure to environmental toxins through proper safety measures and pollution control efforts can help mitigate this risk.

Environmental factors play a significant role in influencing age-related hearing loss, interacting with genetic predispositions to impact auditory health. By understanding and addressing these environmental influences, individuals can take proactive steps to protect their hearing as they age, leading to improved quality of life and well-being.

What are the Types of Hearing Loss?

Hearing loss can be categorized into several distinct types, each with its own underlying causes and characteristics. The main types of hearing loss include:

  • Sensorineural Hearing Loss: Sensorineural hearing loss occurs when there is damage to the delicate hair cells in the inner ear or the auditory nerve pathways that transmit sound signals to the brain. This type of hearing loss is typically permanent and can be caused by a variety of factors, including aging, genetic predispositions, exposure to loud noises, ototoxic medications, and certain medical conditions like Meniere’s disease.
  • Conductive Hearing Loss: Conductive hearing loss occurs when there is a blockage or damage in the outer or middle ear that prevents sound waves from reaching the inner ear. Common causes of conductive hearing loss include ear infections, wax buildup, fluid accumulation in the middle ear, perforated eardrum, or abnormalities in the ear canal or middle ear bones. Conductive hearing loss can often be treated medically or surgically, depending on the underlying cause.
  • Mixed Hearing Loss: Mixed hearing loss is a combination of sensorineural and conductive hearing loss, involving both damage to the inner ear or auditory nerve and obstruction or dysfunction in the outer or middle ear. This type of hearing loss requires a comprehensive evaluation and may involve a combination of medical, surgical, and rehabilitative interventions to address both components.

Understanding the type of hearing loss an individual is experiencing is essential for determining the most appropriate treatment and management strategies. By identifying the underlying causes and characteristics of hearing loss, individuals can work with healthcare professionals to develop personalized plans to preserve and optimize their auditory function.

Can Age-related Hearing Loss or Presbycusis Impact Mental Health?

Age-related hearing loss, or presbycusis, can have a significant impact on mental health. Research has shown a strong association between hearing loss and various cognitive and emotional issues, including depression, social isolation, and cognitive decline. 

The strain of struggling to hear and communicate effectively can lead to feelings of frustration, anxiety, and low self-esteem, particularly in social settings. Social isolation often follows, as individuals may withdraw from social activities and interactions due to difficulties understanding conversations and feeling embarrassed or misunderstood.

Furthermore, untreated hearing loss has been linked to an increased risk of cognitive decline and dementia in older adults. The cognitive load of trying to compensate for hearing difficulties may detract from cognitive resources available for other tasks, potentially contributing to cognitive impairment over time.

Addressing age-related hearing loss through early intervention, such as hearing aids or assistive listening devices, can help mitigate these negative effects on mental health. By improving communication abilities and enhancing social engagement, individuals with presbycusis can maintain their mental well-being and overall quality of life as they age.

What are the Symptoms of Age-related Hearing Loss?

Age-related hearing loss manifests gradually over time and can vary in severity among individuals. Common symptoms of age-related hearing loss include:

  • Difficulty Understanding Speech: Difficulty understanding speech, especially in noisy environments or when multiple people are talking, is a hallmark symptom of age-related hearing loss. Individuals may find themselves frequently asking others to repeat themselves or misunderstanding conversations.
  • Muffled or Distorted Sound Perception: Sounds may appear muffled or distorted to individuals with age-related hearing loss. This can affect their ability to perceive and interpret various auditory cues accurately.
  • Difficulty Hearing High-Frequency Sounds: Age-related hearing loss often initially affects the ability to hear high-frequency sounds, such as the chirping of birds or the ringing of a telephone. As the condition progresses, it may also impact lower-frequency sounds.
  • Increasing Volume on Electronic Devices: Individuals with age-related hearing loss may find themselves needing to increase the volume on televisions, radios, or electronic devices to hear adequately.
  • Tinnitus: Tinnitus, or ringing, buzzing, or hissing sounds in the ears, is commonly associated with age-related hearing loss. It may occur intermittently or persistently and can worsen in quiet environments.
  • Social Withdrawal: Struggling to hear and understand conversations can lead to frustration and embarrassment, prompting individuals to withdraw from social activities and interactions.
  • Fatigue and Stress: The effort required to concentrate and decipher speech can be mentally exhausting, leading to increased feelings of fatigue and stress, especially after prolonged social interactions.

Recognizing these symptoms is essential for early intervention and management of age-related hearing loss. Seeking professional evaluation and hearing assessments can help individuals address their hearing concerns and improve their overall quality of life.

Ways to Reduce Potential of Age-related Hearing Loss

Protecting hearing is essential for maintaining overall well-being, especially as individuals age. Fortunately, several strategies can help reduce the potential for age-related hearing loss. Here are some evidence-based approaches:

Minimize Exposure to Loud Noise

Limiting exposure to loud noises is one of the most effective ways to prevent hearing loss. Individuals should avoid prolonged exposure to noisy environments, such as concerts, construction sites, or loud machinery. When exposure to loud noise is unavoidable, wearing ear protection such as earplugs or noise-canceling headphones can help reduce the risk of damage to the inner ear.

Use Hearing Protection

In situations where exposure to loud noise is unavoidable, wearing hearing protection devices can significantly reduce the risk of hearing damage. Earplugs and earmuffs are effective at blocking out harmful noise levels while still allowing individuals to hear essential sounds, such as conversations or alarms.

Monitor Volume Levels

When listening to music or watching television, individuals should be mindful of the volume levels. Keeping the volume at a moderate level and taking breaks to give the ears a rest can help prevent overexposure to loud sounds and reduce the risk of hearing loss over time.

Maintain Cardiovascular Health

Research has shown a strong link between cardiovascular health and hearing health. Individuals should strive to maintain a healthy lifestyle by exercising regularly, eating a balanced diet rich in fruits, vegetables, and whole grains, managing stress, and avoiding smoking. These lifestyle habits can help improve blood flow to the inner ear and reduce the risk of age-related hearing loss.

Manage Chronic Conditions

Chronic health conditions such as diabetes, hypertension, and high cholesterol can increase the risk of hearing loss. Managing these conditions through medication, lifestyle changes, and regular medical check-ups can help prevent or delay the onset of age-related hearing loss.

Limit Ototoxic Medications

Some medications, including certain antibiotics, chemotherapy drugs, and nonsteroidal anti-inflammatory drugs (NSAIDs), have been associated with hearing loss. Individuals should consult with their healthcare provider about the potential ototoxic effects of medications and explore alternative treatment options whenever possible.

Protect Against Head Trauma

Head injuries can damage the delicate structures of the inner ear and lead to hearing loss. Taking precautions to prevent head trauma, such as wearing helmets during sports or using seat belts while driving, can help protect hearing health.

Get Regular Hearing Screenings

Regular hearing screenings are essential for detecting hearing loss early and implementing appropriate interventions. Adults should undergo hearing evaluations as part of their routine healthcare appointments, especially as they age or if they notice changes in their hearing abilities.

Stay Engaged Socially

Social isolation has been linked to an increased risk of age-related hearing loss and cognitive decline. Staying socially active and engaged can help stimulate the brain and preserve auditory function. Participating in social activities, joining clubs or organizations, and maintaining close relationships with family and friends can all contribute to overall hearing health.

By incorporating these strategies into their daily lives, individuals can take proactive steps to reduce the potential for age-related hearing loss and preserve their hearing as they age.

LifeDNA’s Age-Related Hearing Loss Trait Report

Unlock the secrets of your genetic blueprint with LifeDNA’s report on Age-related Hearing Loss. Designed to provide valuable insights into your predisposition to age-related hearing loss, this comprehensive report empowers you to take control of your hearing health like never before.

Our scientifically backed report delves deep into your unique genetic profile, uncovering key genetic markers associated with age-related hearing loss. By understanding your genetic predispositions, you can make informed decisions about your lifestyle, habits, and nutrition to support optimal hearing health as you age.

At LifeDNA, we believe that nutrition and lifestyle plays a crucial role in overall wellness, including hearing health. That’s why our report on Age-related Hearing Loss doesn’t just stop at genetics – it also provides personalized recommendations tailored to your individual needs. Whether it’s incorporating specific nutrients known to support auditory function or implementing lifestyle changes to protect against environmental factors, our report equips you with the knowledge you need to thrive.

But that’s not all – with over 200 trait reports available across our Wellness, Vitamins and Supplements, Fitness, Personality and Cognition, Sleep, and Skincare categories, LifeDNA offers a comprehensive approach to wellness that goes beyond just genetics. Plus, with premium reports like the Aging Report and Methylation Genes Report, you can gain deeper insights into specific aspects of your health.

Take the first step towards a healthier, happier you today. Avail of LifeDNA’s plans and start your wellness journey with confidence. Your genetic roadmap awaits – uncover the possibilities and embrace your best self with LifeDNA.

Summary

  • Age-related hearing loss (ARHL) is common among older adults, affecting about one-third of individuals by the age of 65.
  • Hearing loss can stem from genetic predispositions, environmental factors, and physiological changes within the inner ear.
  • ARHL typically starts to manifest in individuals in their 40s or 50s, with prevalence increasing significantly after the age of 65.
  • Genetic studies have identified specific genes, such as salt-inducible kinase 3 (SIK3), associated with age-related hearing loss.
  • Environmental factors like noise exposure, ototoxic chemicals, smoking, poor cardiovascular health, and diet can also influence age-related hearing loss.
  • Understanding the different types of hearing loss, including sensorineural, conductive, and mixed, is crucial for effective management and treatment.
  • Age-related hearing loss can impact mental health, leading to social isolation, depression, and cognitive decline.
  • Recognizing symptoms like difficulty understanding speech, muffled sound perception and tinnitus is essential for early intervention.
  • Strategies to reduce the potential for age-related hearing loss include minimizing exposure to loud noise, using hearing protection, monitoring volume levels, maintaining cardiovascular health, managing chronic conditions, limiting ototoxic medications, protecting against head trauma, getting regular hearing screenings, and staying socially engaged.

References

  1. https://www.sciencedirect.com/topics/neuroscience/age-related-hearing-loss
  2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10512576/#:~:text=Age%2Drelated%20hearing%20loss%20(ARHL)%2C%20also%20known%20as,affect%20older%20adults%20%5B2%5D.
  3. https://www.who.int/health-topics/hearing-loss#tab=tab_1
  4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689008/
  5. https://www.hopkinsmedicine.org/health/conditions-and-diseases/presbycusis#:~:text=What%20is%20presbycusis%3F,of%20the%20change%20at%20first.
  6. https://www.ncoa.org/adviser/hearing-aids/presbycusis-age-related-hearing-loss/#:~:text=Presbycusis%20definition&text=It’s%20caused%20by%20damage%20to,older%20in%20the%20United%20States.
  7. https://www.jstor.org/stable/3429484#:~:text=Three%20characteristics%20are%20discussed%20here,and%20(3)%20impulse%20noise.
  8. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482333/
  9. https://www.cdc.gov/niosh/topics/noise/chemicals.html#:~:text=Exposure%20to%20certain%20chemicals%20can,the%20harmful%20effects%20of%20noise.
  10. https://www.healthyhearing.com/report/50940-Smoking-and-hearing-loss#:~:text=Smoking%20is%20a%20well%2Destablished,including%20hearing%20loss.
  11. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9698578/
  12. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4693596/
  13. https://www.asha.org/public/hearing/types-of-hearing-loss/
  14. https://www.ncoa.org/adviser/hearing-aids/presbycusis-age-related-hearing-loss/#:~:text=Presbycusis%2C%20or%20age%2Drelated%20hearing,of%20life%20and%20mental%20health.
  15. https://www.cedars-sinai.org/health-library/diseases-and-conditions/a/age-related-hearing-loss-presbycusis.html
  16. https://www.nia.nih.gov/health/hearing-and-hearing-loss/hearing-loss-common-problem-older-adults#:~:text=Tinnitus%20is%20sometimes%20the%20first,ear%20canal%20can%20cause%20tinnitus.
  17. https://www.nidcd.nih.gov/health/age-related-hearing-loss#:~:text=To%20help%20safeguard%20your%20hearing,with%20earplugs%20or%20protective%20earmuffs.
  18. https://www.cell.com/ajhg/fulltext/S0002-9297(19)30347-7?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0002929719303477%3Fshowall%3Dtrue
  19. https://academic.oup.com/hmg/article/23/23/6407/2900883

*Understanding your genetics can offer valuable insights into your well-being, but it is not deterministic. Your traits can be influenced by the complex interplay involving nature, lifestyle, family history, and others.

Our reports and suggestions do not diagnose or treat any health conditions or provide any medical advice. Consult with a healthcare professional before making any major lifestyle changes or if you have any other concerns about your results.

SHMT Gene And The Methylation Cycle

Aira on May 24, 2024

The SHMT gene encodes the enzyme serine hydroxymethyltransferase, an enzyme essential for amino acid metabolism and nucleotide synthesis. This enzyme catalyzes the conversion of serine and tetrahydrofolate (THF) to glycine and 5,10-methylenetetrahydrofolate (5,10-MTHF). This reaction is essential for various biosynthetic processes, including the methylation cycle and the synthesis of  the nucleotides, the DNA and RNA building blocks. 

The SHMT enzyme supports also the production of thymidylate and purines, which are crucial for cell division and genetic stability. It contributes to the pool of methyl groups needed for methylation reactions that regulate gene expression and protein function. Genetic variations in the SHMT gene can affect its enzyme activity, influencing folate metabolism, homocysteine levels, and overall cellular health. These variations are associated with cardiovascular diseases, neural tube defects, and certain cancers, underscoring the gene’s importance in maintaining metabolic balance and preventing disease.

Overview of the Methylation Cycle

The central theme of the methylation cycle is the conversion of homocysteine, a potentially harmful substance, to methionine, an essential amino acid. The methylation cycle helps keep your homocysteine levels in check. High homocysteine levels can lead to several health issues.

Here are the steps in the methylation cycle involving key enzymes and intermediates:

[1] Conversion of Serine to Glycine [we are here]

  • Enzyme: Serine Hydroxymethyltransferase (SHMT)
  • Reaction: Serine + Tetrahydrofolate (THF) → Glycine + 5,10-Methylenetetrahydrofolate (5,10-MTHF)

[2] Conversion of 5,10-MTHF to 5-MTHF

  • Enzyme: Methylenetetrahydrofolate Reductase (MTHFR)
  • Reaction: 5,10-Methylenetetrahydrofolate (5,10-MTHF) → 5-Methyltetrahydrofolate (5-MTHF)

[3] Conversion of Homocysteine to Methionine

  • Enzyme: Methionine Synthase (MTR)
  • Reaction: Homocysteine + 5-Methyltetrahydrofolate (5-MTHF) → Methionine + Tetrahydrofolate (THF)
  • Coenzyme: Methionine Synthase Reductase (MTRR) keeps MTR active

[4] Alternative Pathway for Homocysteine to Methionine

  • Enzyme: Betaine-Homocysteine Methyltransferase (BHMT)
  • Reaction: Homocysteine + Betaine → Methionine + Dimethylglycine

[5] Conversion of Methionine to SAM

  • Enzyme: Methionine Adenosyltransferase (MAT)
  • Reaction: Methionine + ATP → S-Adenosylmethionine (SAM)

[6] Methylation Reactions

  • SAM as Methyl Donor: SAM donates a methyl group to various substrates (DNA, RNA, proteins, lipids) and becomes S-Adenosylhomocysteine (SAH).

[7] Conversion of SAH to Homocysteine

  • Enzyme: S-Adenosylhomocysteine Hydrolase (SAHH)
  • Reaction: S-Adenosylhomocysteine (SAH) → Homocysteine + Adenosine

[8] Transsulfuration Pathway (Alternative route for homocysteine) 

  • Enzyme: Cystathionine Beta-Synthase (CBS)
  • Reaction: Homocysteine + Serine → Cystathionine
  • Subsequent Reaction: Cystathionine converts to cysteine and other metabolites.

Importance of Healthy Homocysteine Levels

Homocysteine levels are essential because elevated levels of homocysteine, a sulfur-containing amino acid, are associated with an increased risk of cardiovascular diseases, including coronary artery disease, stroke, and peripheral arterial disease. High homocysteine levels can damage the lining of arteries, promote blood clot formation, and increase oxidative stress, all of which contribute to the development and progression of atherosclerosis. 

Additionally, elevated homocysteine is associated with other health issues such as cognitive decline, dementia, and certain birth flaws. Monitoring and managing homocysteine levels through diet, lifestyle changes, and, in some cases, medication can be crucial for maintaining cardiovascular health and preventing related complications.

SHMT

Overview of the Methylation Cycle

The central theme of the methylation cycle is the conversion of homocysteine, the harmful substance, to methionine, an essential amino acid. The methylation cycle helps keep your homocysteine levels in check. As discussed in the earlier section, high homocysteine levels can lead to several health issues.

Here are the steps in the methylation cycle involving key enzymes and intermediates:

[1] Conversion of Serine to Glycine

  • Enzyme: Serine Hydroxymethyltransferase (SHMT)
  • Reaction: Serine + Tetrahydrofolate (THF) → Glycine + 5,10-Methylenetetrahydrofolate (5,10-MTHF)

[2] Conversion of 5,10-MTHF to 5-MTHF

  • Enzyme: Methylenetetrahydrofolate Reductase (MTHFR)
  • Reaction: 5,10-Methylenetetrahydrofolate (5,10-MTHF) → 5-Methyltetrahydrofolate (5-MTHF)

[3] Conversion of Homocysteine to Methionine [we are here]

  • Enzyme: Methionine Synthase (MTR)
  • Reaction: Homocysteine + 5-Methyltetrahydrofolate (5-MTHF) → Methionine + Tetrahydrofolate (THF)
  • Coenzyme: Methionine Synthase Reductase (MTRR) keeps MTR active

[4] Alternative Pathway for Homocysteine to Methionine

  • Enzyme: Betaine-Homocysteine Methyltransferase (BHMT)
  • Reaction: Homocysteine + Betaine → Methionine + Dimethylglycine

[5] Conversion of Methionine to SAM

  • Enzyme: Methionine Adenosyltransferase (MAT)
  • Reaction: Methionine + ATP → S-Adenosylmethionine (SAM)

[6] Methylation Reactions

  • SAM as Methyl Donor: SAM donates a methyl group to various substrates (DNA, RNA, proteins, lipids) and becomes S-Adenosylhomocysteine (SAH).

[7] Conversion of SAH to Homocysteine

  • Enzyme: S-Adenosylhomocysteine Hydrolase (SAHH)
  • Reaction: S-Adenosylhomocysteine (SAH) → Homocysteine + Adenosine

[8] Transsulfuration Pathway (Alternative route for homocysteine)

  • Enzyme: Cystathionine Beta-Synthase (CBS)
  • Reaction: Homocysteine + Serine → Cystathionine
  • Subsequent Reaction: Cystathionine converts to cysteine and other metabolites.

SHMT Gene and the Methylation Cycle

The SHMT gene plays a critical role in the methylation cycle, a crucial biochemical pathway in DNA synthesis, repair, and gene regulation. The enzyme encoded by the SHMT gene, the serine hydroxymethyltransferase, catalyzes the conversion of serine and tetrahydrofolate (THF) to glycine and 5,10-methylenetetrahydrofolate (5,10-MTHF). This reaction is integral to one-carbon metabolism, which provides the necessary methyl groups for the methylation cycle.

Role of the SHMT Gene in the Methylation Cycle

Production of 5,10-Methylenetetrahydrofolate (5,10-MTHF)

The SHMT enzyme produces 5,10-MTHF and is a crucial intermediate that sets off the methylation cycle. 5,10-MTHF is essential for synthesizing nucleotides for DNA replication and repair.

Regeneration of Methionine from Homocysteine

In the methylation cycle, homocysteine converts back to methionine using methyl groups provided by 5-methyltetrahydrofolate (5-MTHF), derived from 5,10-MTHF. This step is critical for maintaining adequate levels of methionine and S-adenosylmethionine (SAM), the body’s primary methyl donor.

Support for Methylation Reactions

SAM, produced from methionine, is used in numerous methylation reactions, including DNA methylation, which regulates gene expression, as well as the methylation of proteins and lipids. The proper functioning of the SHMT enzyme ensures a steady supply of one-carbon units needed for these reactions.

Interplay with Folate Metabolism

The SHMT gene links the folate cycle with the methylation cycle. Folate (B9), in the form of THF, is required for the SHMT enzyme to produce 5,10-MTHF. Adequate folate levels are thus necessary for the proper function of the methylation cycle and overall cellular health.

Implications of SHMT Gene Polymorphisms

The SHMT1 gene C1420T polymorphism (rs1979277 C>T/G>A), which involves a change from cytosine (C) to thymine (T) at position 1420 in the SHMT1 gene, can impact health in several ways due to its role in one-carbon metabolism and the methylation cycle. Here are the key health impacts associated with this polymorphism:

Folate Metabolism

The serine hydroxymethyltransferase enzyme, encoded by the SHMT gene, converts serine and tetrahydrofolate (THF) to glycine and 5,10-methylenetetrahydrofolate (5,10-MTHF). This reaction is crucial for maintaining proper folate (B9) metabolism. The presence of the T allele at  the SHMT1 C1420T locus may influence the enzyme’s efficiency, potentially altering folate levels in the body.

Homocysteine Levels

The T-allele of the SHMT C1420T polymorphism is associated with higher homocysteine levels, which is a risk factor for cardiovascular and neurodegenerative diseases. This increase in homocysteine levels suggests that individuals with the T-allele may have a higher demand for folate to maintain normal homocysteine metabolism and prevent hyperhomocysteinemia.

Vitamin B12 Interaction

In vitamin B12 metabolism, the SHMT C1420T polymorphism may interact with other genetic factors and vitamin levels to influence health outcomes. Adequate intake of folate and vitamin B12 is essential to mitigate the potential unfavorable effects of this polymorphism.

Genotype-Specific Health Management

Individuals with the SHMT1 1420T allele (rs1979277-A) may benefit from personalized health management strategies, including dietary adjustments to ensure sufficient folate and vitamin B12 intake, regular monitoring of homocysteine levels, and preventive measures for cardiovascular and neurodegenerative diseases.

Get your LifeDNA Methylation Genes report to understand your SHMT and other methylation gene polymorphisms in detail. 

Optimize Your Homocysteine Levels Naturally

To optimize homocysteine levels through diet, focus on the following strategies:

  • Increase Folate (Vitamin B9) Intake: Leafy greens (spinach, kale), legumes (beans, lentils), fruits (oranges, bananas), fortified cereals. Folate helps convert homocysteine into methionine, reducing its levels.
  • Boost Vitamin B12 (Cobalamin) Intake: Meat (beef, chicken), fish (salmon, tuna), dairy products (milk, cheese), fortified plant-based milk or cereals. Vitamin B12 is crucial for converting homocysteine into methionine, helping to lower homocysteine levels.
  • Consume More Vitamin B6 (Pyridoxine): Poultry (chicken, turkey), fish (salmon, tuna), potatoes, bananas, and fortified cereals. Vitamin B6 helps convert homocysteine to cysteine, another amino acid, lowering homocysteine levels.
  • Increase Riboflavin (Vitamin B2) Intake: Dairy products (milk, yogurt), eggs, lean meats, green leafy vegetables, and fortified cereals. Riboflavin supports the activity of enzymes involved in homocysteine metabolism.
  • Ensure Adequate Choline Intake: Eggs, beef liver, chicken, shrimp, and soybeans. Choline helps produce betaine, which aids in converting homocysteine to methionine.
  • Limit Alcohol Consumption: Alcohol can impair the function of enzymes involved in homocysteine metabolism and exacerbate high homocysteine levels.
  • Include Antioxidant-Rich Foods: Fruits (berries, oranges), vegetables (broccoli, bell peppers), nuts, and seeds. Antioxidants can help protect against oxidative stress, which may be high with homocysteine levels.
  • Consider Omega-3 Fatty Acids: Fatty fish (salmon, mackerel), flaxseeds, chia seeds, and walnuts. Omega-3 fatty acids tend to lower homocysteine levels and improve heart health.

Incorporating these nutrient-rich foods into your diet can help maintain healthy homocysteine levels and support overall cardiovascular health. Always consult with a healthcare professional before making significant changes to your diet or starting new supplements.

References

  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609604/ 
  2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936891/

*Understanding your genetics can offer valuable insights into your well-being, but it is not deterministic. Your traits can be influenced by the complex interplay involving nature, lifestyle, family history, and others.

Our reports have not been evaluated by the Food and Drug Administration. The contents on our website and our reports are for informational purposes only, and are not intended to diagnose any medical condition, replace the advice of a healthcare professional, or provide any medical advice, diagnosis, or treatment. Consult with a healthcare professional before making any major lifestyle changes or if you have any other concerns about your results. The testimonials featured may have used more than one LifeDNA or LifeDNA vendors’ product or reports.

MTRR and MTR Genes and the Methylation Cycle

Aira on May 24, 2024

Disclaimer: This article does not include all possible risk variants for the MTRR and MTR and is only for informational purposes. This article is not intended for diagnosis. Please talk to a healthcare professional if you have symptoms associated with these variants.

Why is the Methylation Cycle Important For You?

The methylation cycle is essential for numerous biological processes and overall health. Protein methylation detoxifies harmful substances, including heavy metals and toxins, thus protecting the body and supporting liver function. 

Methylation  also affects neurotransmitter production and regulation, influencing mood, cognition, and mental health. The methylation cycle helps regulate homocysteine levels, reducing the risk of cardiovascular diseases like heart disease and stroke. Furthermore, it is involved in energy production by synthesizing creatine and carnitine, both essential for metabolism and muscle function. 

Finally, methylation modulates the immune system, supporting the production and function of immune cells, which are crucial for combating infections and diseases. The methylation cycle is fundamental to many aspects of health and well-being.

Importance of Healthy Homocysteine Levels

Homocysteine levels are significant because elevated levels of homocysteine, a sulfur-containing amino acid, are associated with an increased risk of cardiovascular diseases, including coronary artery disease, stroke, and peripheral arterial disease. High homocysteine levels can damage the lining of arteries, promote blood clot formation, and increase oxidative stress, all of which contribute to the development and progression of atherosclerosis. 

Additionally, elevated homocysteine is associated with other health issues such as cognitive decline, dementia, and certain birth flaws. Monitoring and managing homocysteine levels through diet, lifestyle changes, and, in some cases, medication, can be crucial for maintaining cardiovascular health and preventing related complications.

Methylation Genes Report

Overview of the Methylation Cycle

The central theme of the methylation cycle is the conversion of homocysteine, the harmful substance, to methionine, an essential amino acid. The methylation cycle helps keep your homocysteine levels in check. As discussed in the earlier section, high homocysteine levels can lead to several health issues.

Here are the steps in the methylation cycle involving key enzymes and intermediates:

[1] Conversion of Serine to Glycine

  • Enzyme: Serine Hydroxymethyltransferase (SHMT)
  • Reaction: Serine + Tetrahydrofolate (THF) → Glycine + 5,10-Methylenetetrahydrofolate (5,10-MTHF)

[2] Conversion of 5,10-MTHF to 5-MTHF

  • Enzyme: Methylenetetrahydrofolate Reductase (MTHFR)
  • Reaction: 5,10-Methylenetetrahydrofolate (5,10-MTHF) → 5-Methyltetrahydrofolate (5-MTHF)

[3] Conversion of Homocysteine to Methionine [we are here]

  • Enzyme: Methionine Synthase (MTR)
  • Reaction: Homocysteine + 5-Methyltetrahydrofolate (5-MTHF) → Methionine + Tetrahydrofolate (THF)
  • Coenzyme: Methionine Synthase Reductase (MTRR) keeps MTR active

[4] Alternative Pathway for Homocysteine to Methionine

  • Enzyme: Betaine-Homocysteine Methyltransferase (BHMT)
  • Reaction: Homocysteine + Betaine → Methionine + Dimethylglycine

[5] Conversion of Methionine to SAM

  • Enzyme: Methionine Adenosyltransferase (MAT)
  • Reaction: Methionine + ATP → S-Adenosylmethionine (SAM)

[6] Methylation Reactions

  • SAM as Methyl Donor: SAM donates a methyl group to various substrates (DNA, RNA, proteins, lipids) and becomes S-Adenosylhomocysteine (SAH).

[7] Conversion of SAH to Homocysteine

  • Enzyme: S-Adenosylhomocysteine Hydrolase (SAHH)
  • Reaction: S-Adenosylhomocysteine (SAH) → Homocysteine + Adenosine

[8] Transsulfuration Pathway (Alternative route for homocysteine)

  • Enzyme: Cystathionine Beta-Synthase (CBS)
  • Reaction: Homocysteine + Serine → Cystathionine
  • Subsequent Reaction: Cystathionine converts to cysteine and other metabolites.

MTR and MTRR in the Methylation Cycle

The MTR and MTRR genes enter the methylation cycle in the third step, which is the conversion of homocysteine to methionine. Methionine is an essential amino acid that plays a crucial role in various bodily functions, including the synthesis of proteins, which are the building blocks of our cells. Methionine is also vital for SAM, a compound that helps with methylation, detoxifies harmful substances, and supports overall cell function. Foods rich in methionine include meat, fish, dairy products, nuts, and seeds.

The MTR gene  produces themethionine synthase enzyme crucial for the methylation cycle. This enzyme catalyzes the conversion of homocysteine, a potentially harmful amino acid, into methionine, an essential amino acid necessary for protein synthesis and other metabolic functions. Methionine is then converted into S-adenosylmethionine (SAM), a key methyl donor involved in numerous methylation reactions that regulate DNA synthesis, repair, and gene expression.

The MTRR gene, encodes for the methionine synthase reductase coenzyme which ensures the continuous activity of methionine synthase enzyme (encoded by the MTR gene). Methionine synthase can become inactive during the conversion of homocysteine to methionine, and methionine synthase reductase reactivates it, allowing the cycle to proceed smoothly. The MTR and MTRR genes maintain proper homocysteine levels and support the methylation cycle, which is vital for many cellular functions and overall health.

How This Can Affect You?

Polymorphisms in the MTR and MTRR genes can directly impact homocysteine levels, and  can therefore influence many health aspects.

Some studies have found that risk variants in the MTR and MTRR genes are associated with difficulties using methylcobalamin, a form of vitamin B12, and producing methionine. Methylcobalamin is a coenzyme that helps convert homocysteine to methionine. Individuals with these risk variants may have lower B12 levels because the MTR enzyme uses B12 more quickly. Vitamin B12 is crucial for DNA synthesis, cell division, red blood cell formation, energy production, mood regulation, and other essential bodily functions. Additionally, those with the risk variants may have higher homocysteine levels, particularly if their B12 levels are low, and elevated homocysteine levels have been associated with an increased risk of cardiovascular problems.

A 2007 study examined the association between MTR (A2756G, rs1805087 A>G) and MTRR (A66G, rs1801394 A>G) gene polymorphisms and levels of total homocysteine in 275 healthy women in labor who delivered full-term normal babies. Results showed that the MTR and MTRR genotypes could predict total homocysteine levels, sometimes depending on the serum folate or cobalamin levels. However, women with  MTR 2756AA had statistically significantly higher total homocysteine levels independently of the other factors. 

Get your LifeDNA Methylation Genes report to understand your MTR, MTRR and other methylation gene polymorphisms in detail. 

Optimize Your Homocysteine Levels Naturally

To optimize homocysteine levels through diet, focus on the following strategies:

  • Increase Folate (Vitamin B9) Intake: Leafy greens (spinach, kale), legumes (beans, lentils), fruits (oranges, bananas), fortified cereals. Folate helps convert homocysteine into methionine, reducing its levels.
  • Boost Vitamin B12 (Cobalamin) Intake: Meat (beef, chicken), fish (salmon, tuna), dairy products (milk, cheese), fortified plant-based milk or cereals. Vitamin B12 is crucial for converting homocysteine into methionine, helping to lower homocysteine levels.
  • Consume More Vitamin B6 (Pyridoxine): Poultry (chicken, turkey), fish (salmon, tuna), potatoes, bananas, and fortified cereals. Vitamin B6 helps convert homocysteine to cysteine, another amino acid, lowering homocysteine levels.
  • Increase Riboflavin (Vitamin B2) Intake: Dairy products (milk, yogurt), eggs, lean meats, green leafy vegetables, and fortified cereals. Riboflavin supports the activity of enzymes involved in homocysteine metabolism.
  • Ensure Adequate Choline Intake: Eggs, beef liver, chicken, shrimp, and soybeans. Choline helps produce betaine, which aids in converting homocysteine to methionine.
  • Limit Alcohol Consumption: Alcohol can impair the function of enzymes involved in homocysteine metabolism and exacerbate high homocysteine levels.
  • Include Antioxidant-Rich Foods: Fruits (berries, oranges), vegetables (broccoli, bell peppers), nuts, and seeds. Antioxidants can help protect against oxidative stress, which may be high with homocysteine.
  • Consider Omega-3 Fatty Acids: Fatty fish (salmon, mackerel), flaxseeds, chia seeds, and walnuts. Omega-3 fatty acids have been associated with lower homocysteine levels and improved heart health.

Incorporating these nutrient-rich foods into your diet can help maintain healthy homocysteine levels and support overall cardiovascular health. Always consult with a healthcare professional before making significant changes to your diet or starting new supplements.

References

  1. https://doi.org/10.1016/j.thromres.2006.05.009
  2. https://www.nature.com/articles/1602810 
  3. https://my.clevelandclinic.org/health/articles/21527-homocysteine
  4. https://medlineplus.gov/genetics/gene/mtr/
  5. https://medlineplus.gov/genetics/gene/mtrr/

*Understanding your genetics can offer valuable insights into your well-being, but it is not deterministic. Your traits can be influenced by the complex interplay involving nature, lifestyle, family history, and others.

Our reports have not been evaluated by the Food and Drug Administration. The contents on our website and our reports are for informational purposes only, and are not intended to diagnose any medical condition, replace the advice of a healthcare professional, or provide any medical advice, diagnosis, or treatment. Consult with a healthcare professional before making any major lifestyle changes or if you have any other concerns about your results. The testimonials featured may have used more than one LifeDNA or LifeDNA vendors’ product or reports.

Facebook Twitter Instagram

Menu

Support

Stay up to date on the latest from LifeDNA

2024 LifeDNA, Inc. All rights reserved.